Extrachromosomal circular DNA of tandemly repeated genomic sequences in Drosophila.

doi:10.1101/gr.907603

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Article

Extrachromosomal circular DNA of tandemly repeated genomic sequences in Drosophila.

Genome research - 1 Jun 2003

Cohen Sarit, Yacobi Keren, Segal Daniel

Abstract excerpt

One characteristic of genomic plasticity is the presence of extrachromosomal circular DNA (eccDNA). This DNA is found in various eukaryotes from yeast to humans, and its levels are elevated by exposure to carcinogens. eccDNA is heterogeneous in size and composed of chromosomal sequences. In this study we used two-dimensional gel electrophoresis to detect and characterize eccDNA in Drosophila. We found eccDNA...

Topics

Animals
Chromosome Mapping
DNA, Circular
DNA, Ribosomal
DNA, Satellite
Drosophila Proteins
Drosophila melanogaster
Electrophoresis, Gel, Two-Dimensional
Extrachromosomal Inheritance
Genes, Insect
Genome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterochromatin

Larva

Life Cycle Stages

Methyl Methanesulfonate

Multigene Family

Mutation

RNA, Ribosomal, 5S

Source

Open in PubMed Open full text

Identifiers

PMID: 12799349
DOI: 10.1101/gr.907603
PMCID: PMC403641

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