Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT).

Journal of molecular biology - 20 Jun 2003

Gassel Michael, Breitenlechner Christine B, Rüger Petra, Jucknischke Ute, Schneider Thorsten, Huber Robert, Bossemeyer Dirk, Engh Richard A

Abstract excerpt

The mutation of well behaved enzymes in order to simulate less manageable cognates is the obvious approach to study specific features of the recalcitrant target. Accordingly, the prototypical protein kinase PKA serves as a model for many kinases, including the closely related PKB, an AGC family protein kinase now implicated as oncogenic in several cancers. Two residues that differ between the alpha isoforms of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Biosensing Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

Share to Cyclic AMP-Dependent Protein Kinases

Share to Magnesium

Share to Molecular Mimicry

Share to Proto-Oncogene Proteins c-akt

Share to Sulfur

Source

Identifiers

PMID: 12798691
DOI: 10.1016/s0022-2836(03)00518-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT).PMID 12798691Read ↗

Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants.Semantic proximity Read ↗

Folding and activity of cAMP-dependent protein kinase mutants.Semantic proximity Read ↗

A Chemical-genetics and Nanoparticle Enabled Approach for <i>in vivo</i> Protein Kinase AnalysisSemantic proximity Read ↗

Identifying critical non-catalytic residues that modulate protein kinase A activity.Semantic proximity Read ↗

A QM/MM study of the associative mechanism for the phosphorylation reaction catalyzed by protein kinase A and its D166A mutant.Semantic proximity Read ↗

Kinetic characterization of the double mutant R148A/E182S of glycogen phosphorylase kinase catalytic subunit: the role of the activation loop.Semantic proximity Read ↗

Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?Semantic proximity Read ↗

Global consequences of activation loop phosphorylation on protein kinase A.Semantic proximity Read ↗

Water-mediated conformational preselection mechanism in substrate binding cooperativity to protein kinase A.Semantic proximity Read ↗

C-spine mutations of protein kinase C and Akt as a novel generalizable approach to create stable pseudokinases.Semantic proximity Read ↗

Role of the αC-β4 loop in protein kinase structure and dynamics.Semantic proximity Read ↗

Protein engineering of protein kinase A catalytic subunits results in the acquisition of novel inhibitor sensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.