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Features of Isoforms of Human Soluble TACI

5 Jun 2023

Abstract excerpt

The BAFF/APRIL-system with the two cytokines BAFF and APRIL and their three receptors, transmembrane activator and CAML interactor (TACI), BAFF receptor, and B-cell maturation Ag, is important for B cell maintenance. The BAFF/APRIL system is a therapeutic target in B cell-derived malignancies and autoimmune diseases. However, unexpected outcomes of clinical trials with atacicept (TACI-Fc) underline our incomplete...

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PMID: 37272840
DOI: 10.4049/jimmunol.2101107

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