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Article

Stimulation of protein kinase C inhibits bursting in disease-linked mutant human cardiac sodium channels.

Circulation - 1 Jul 2003

Tateyama M, Kurokawa J, Terrenoire C, Rivolta I, Kass R S

Abstract excerpt

BACKGROUND: Mutations in SCN5A, the gene coding for the human cardiac Na+ channel alpha-subunit, are associated with variant 3 of the long-QT syndrome (LQT-3). Several LQT-3 mutations promote a mode of Na+ channel gating in which a fraction of channels fail to inactivate, contributing sustained Na+ channel current (Isus), which can delay repolarization and prolong the QT interval. Here, we investigate the...

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Identifiers

PMID: 12796143
DOI: 10.1161/01.CIR.0000070936.65183.97

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Stimulation of protein kinase C inhibits bursting in disease-linked mutant human cardiac sodium channels.PMID 12796143Read ↗

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