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Article

Differential modulation of late sodium current by protein kinase A in R1623Q mutant of LQT3.

Life sciences - 13 Mar 2009

Tsurugi Takuo, Nagatomo Toshihisa, Abe Haruhiko, Oginosawa Yasushi, Takemasa Hiroko, Kohno Ritsuko, Makita Naomasa, Makielski Jonathan C, Otsuji Yutaka

Abstract excerpt

AIMS: In the type 3 long QT syndrome (LQT3), shortening of the QT interval by overdrive pacing is used to prevent life-threatening arrhythmias. However, it is unclear whether accelerated heart rate induced by beta-adrenergic agents produces similar effects on the late sodium current (I(Na)) to th...

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Identifiers

PMID: 19167409
DOI: 10.1016/j.lfs.2009.01.001
PMCID: PMC2747087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19167409-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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