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Article

Impaired IKs channel activation by Ca(2+)-dependent PKC shows correlation with emotion/arousal-triggered events in LQT1.

Journal of molecular and cellular cardiology - 1 Feb 2015

O-Uchi Jin, Rice J Jeremy, Ruwald Martin H, Parks Xiaorong Xu, Ronzier Elsa, Moss Arthur J, Zareba Wojciech, Lopes Coeli M

Abstract excerpt

BACKGROUND: The most common inherited cardiac arrhythmia, LQT1, is due to IKs potassium channel mutations and is linked to high risk of adrenergic-triggered cardiac events. We recently showed that although exercise-triggered events are very well treated by ß-blockers for these patients, acute arousal-triggered event rate were not significantly reduced after beta-blocker treatment, suggesting that the mechanisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Potassium Channels, Voltage-Gated

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Source

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Identifiers

PMID: 25479336
DOI: 10.1016/j.yjmcc.2014.11.020
PMCID: PMC4302024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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