Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A.

American journal of physiology. Heart and circulatory physiology - 1 Oct 2009

Valdivia Carmen R, Ueda Kazuo, Ackerman Michael J, Makielski Jonathan C

Abstract excerpt

The SCN5A-encoded cardiac sodium channel underlies excitability in the heart, and dysfunction of sodium current (I(Na)) can cause fatal ventricular arrhythmia in maladies such as long QT syndrome, Brugada syndrome (BrS), and sudden infant death syndrome (SIDS). The gene GPD1L encodes the glycerol...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brugada Syndrome
Share to Death, Sudden, Cardiac
Share to Glycerolphosphate Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycerophosphates

Share to NAV1.5 Voltage-Gated Sodium Channel

Share to Protein Kinase C

Share to Sodium

Share to Sudden Infant Death

Source

Open in PubMed Open full text

Identifiers

PMID: 19666841
DOI: 10.1152/ajpheart.00513.2009
PMCID: PMC2770765

Genes

GPD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19666841-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A.PMID 19666841Read ↗

Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndrome.Semantic proximity Read ↗

Whole-exome sequencing identifies a novel mutation of GPD1L (R189X) associated with familial conduction disease and sudden death.Semantic proximity Read ↗

Cardiac Na+ current regulation by pyridine nucleotides.Semantic proximity Read ↗

A novel mutation in GPD1‑L associated with early repolarization syndrome via modulation of cardiomyocyte fast sodium currents.Semantic proximity Read ↗

Mutation analysis of the glycerol-3 phosphate dehydrogenase-1 like (GPD1L) gene in Japanese patients with Brugada syndrome.Semantic proximity Read ↗

Lysine245 plays a crucial role in stability and function of glycerol 3-phosphate dehydrogenase (Gpd1) in Saccharomyces cerevisiae.Semantic proximity Read ↗

Stimulation of protein kinase C inhibits bursting in disease-linked mutant human cardiac sodium channels.Semantic proximity Read ↗

[Gene detection of GPD1-L and the association with sudden unexplained death syndrome in young adults].Semantic proximity Read ↗

SGD1 encodes an essential nuclear protein of Saccharomyces cerevisiae that affects expression of the GPD1 gene for glycerol 3-phosphate dehydrogenase.Semantic proximity Read ↗

GDI-1 phosphorylation switch at serine 96 induces RhoA activation and increased endothelial permeability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.