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Article

Conserved cholecystokinin receptor transmembrane domain IV amino acids confer peptide affinity.

Journal of molecular neuroscience : MN - 1 Apr 2003

Ren Yong, Bläker Michael, Seshadri Lakshmi, McBride Edward W, Beinborn Martin, Kopin Alan S

Abstract excerpt

The Cholecystokinin type 1 and type 2 receptors (CCK-1R and CCK-2R) share >50% amino acid identity, as well as subnanomolar affinity for the endogenous peptide cholecystokinin octapeptide (CCK-8). Although it is likely that these two receptor subtypes share amino acids that confer CCK-8 affinity, it has been difficult to identify such residues. We have examined the role of several transmembrane domain (TMD) IV...

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Identifiers

PMID: 12794305
DOI: 10.1385/JMN:20:2:115

Genes

CCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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