Article
Refinement of the conformation of a critical region of charge-charge interaction between cholecystokinin and its receptor.
Molecular pharmacology - 1 May 2002
Ding Xi-Qin, Pinon Delia I, Furse Kristina E, Lybrand Terry P, Miller Laurence J
Abstract excerpt
Insight into the molecular basis of cholecystokinin (CCK) binding to its receptor has come from receptor mutagenesis and photoaffinity labeling studies, with both contributing to the current hypothesis that the acidic Tyr-sulfate-27 residue within the peptide is situated adjacent to basic Arg(197) in the second loop of the receptor. Here, we refine our understanding of this region of interaction by examining a...
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