Article
Minor modifications of a cholecystokinin-B/gastrin receptor non-peptide antagonist confer a broad spectrum of functional properties.
The Journal of biological chemistry - 5 Jun 1998
Beinborn M, Quinn S M, Kopin A S
Abstract excerpt
The development of non-peptide agonists for peptide hormone receptors would markedly expand the treatment options for a large number of diseases. However, difficulty in identifying non-peptide molecules which possess intrinsic activity has been a major obstacle in achieving this goal. At present,...
Topics
- Animals
- Benzodiazepines
- Benzodiazepinones
- Binding, Competitive
- COS Cells
- Hormone Antagonists
- Inositol Phosphates
- Molecular Structure
- Mutation
- Peptides
- Phenylurea Compounds
- Receptors, Cholecystokinin
- Signal Transduction
- Transfection