Article
Structure of cholecystokinin receptor binding sites and mechanism of activation/inactivation by agonists/antagonists.
Pharmacology & toxicology - 1 Dec 2002
Fourmy Daniel, Escrieut Chantal, Archer Elodie, Galès Céline, Gigoux Véronique, Maigret Bernard, Moroder Luis, Silvente-Poirot Sandrine, Martinez Jean, Fehrentz Jean-Alain, Pradayrol Lucien
Abstract excerpt
Delineation of CCK receptor binding sites is a prerequisite for the understanding of the molecular basis for ligand recognition, partial agonism, ligand-induced traffiking of receptor signalling. In the current paper, we illustrate how, in the past 5 years, studies from our laboratory and others have provided new data on the molecular basis of the pharmacology and functioning of CCK1 and CCK2 receptors. Available...
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