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Article

Molecular mechanism underlying partial and full agonism mediated by the human cholecystokinin-1 receptor.

The Journal of biological chemistry - 18 Mar 2005

Archer-Lahlou Elodie, Escrieut Chantal, Clerc Pascal, Martinez Jean, Moroder Luis, Logsdon Craig, Kopin Alan, Seva Catherine, Dufresne Marlène, Pradayrol Lucien, Maigret Bernard, Fourmy Daniel

Abstract excerpt

The cholecystokinin-1 receptor (CCK1R) is a G protein-coupled receptor (GPCR) that regulates important physiological functions. As for other GPCRs, the molecular basis of full and partial agonism is still far from clearly understood. In the present report, using both laboratory experiments and molecular modeling approaches, we have investigated the partial agonism mechanism of JMV 180, on the human CCK1R. We...

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PMID: 15632187
DOI: 10.1074/jbc.M409451200

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CCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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