Article
A small molecule accelerates neuronal differentiation in the adult rat.
Proceedings of the National Academy of Sciences of the United States of America - 21 Sept 2010
Wurdak Heiko, Zhu Shoutian, Min Kyung Hoon, Aimone Lindsey, Lairson Luke L, Watson James, Chopiuk Gregory, Demas James, Charette Bradley, Halder Rajkumar, Weerapana Eranthie, Cravatt Benjamin F, Cline Hollis T, Peters Eric C, Zhang Jay, Walker John R, Wu Chunlei, Chang Jonathan, Tuntland Tove, Cho Charles Y, Schultz Peter G
Abstract excerpt
Adult neurogenesis occurs in mammals and provides a mechanism for continuous neural plasticity in the brain. However, little is known about the molecular mechanisms regulating hippocampal neural progenitor cells (NPCs) and whether their fate can be pharmacologically modulated to improve neural plasticity and regeneration. Here, we report the characterization of a small molecule (KHS101) that selectively induces a...
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