Article
Identification of a mutated receptor-like protein tyrosine phosphatase kappa as a novel, class II HLA-restricted melanoma antigen.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2003
Novellino Luisa, Renkvist Nicolina, Rini Francesca, Mazzocchi Arabella, Rivoltini Licia, Greco Angela, Deho Paola, Squarcina Paola, Robbins Paul F, Parmiani Giorgio, Castelli Chiara
Abstract excerpt
Recent studies increasingly point to a pivotal role of CD4(+) T cells in human anti-tumor immune response. Here we show that lymphocytes purified from a tumor-infiltrated lymph node of a melanoma patient that had remained disease free for 10 years after surgical resection of a lymph node metastasis comprised oligoclonal class II HLA-restricted CD4(+) T cells recognizing the autologous tumor cells in vitro. In...
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