Article
Identification of tumor-associated, MHC class II-restricted phosphopeptides as targets for immunotherapy.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 2009
Depontieu Florence R, Qian Jie, Zarling Angela L, McMiller Tracee L, Salay Theresa M, Norris Andrew, English A Michelle, Shabanowitz Jeffrey, Engelhard Victor H, Hunt Donald F, Topalian Suzanne L
Abstract excerpt
The activation and recruitment of CD4(+) T cells are critical for the development of efficient antitumor immunity and may allow for the optimization of current cancer immunotherapy strategies. Searching for more optimal and selective targets for CD4(+) T cells, we have investigated phosphopeptides, a new category of tumor-derived epitopes linked to proteins with vital cellular functions. Although MHC I-restricted...
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