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Article

Biochemical identification of a mutated human melanoma antigen recognized by CD4(+) T cells.

The Journal of experimental medicine - 1 Mar 1999

Pieper R, Christian R E, Gonzales M I, Nishimura M I, Gupta G, Settlage R E, Shabanowitz J, Rosenberg S A, Hunt D F, Topalian S L

Abstract excerpt

CD4(+) T cells play a critical role in generating and maintaining immune responses against pathogens and alloantigens, and evidence suggests an important role for them in antitumor immunity as well. Although major histocompatibility complex class II-restricted human CD4(+) T cells with specific antitumor reactivities have been described, no standard method exists for cloning the recognized tumor-associated...

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Topics

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Share to Antigens, Neoplasm
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line

Share to Epitopes

Share to HLA-DR1 Antigen

Share to Lymphocytes, Tumor-Infiltrating

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Source

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Identifiers

PMID: 10049939
DOI: 10.1084/jem.189.5.757
PMCID: PMC2192954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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