Influence of mouse genotype and bacterial virulence in the generation of interferon-gamma-producing cells during the early phase of Salmonella typhimurium infection.

Abstract excerpt

Interferon-gamma (IFN-gamma) is known to play a major role in resistance to Salmonella typhimurium infection. In this study, the IFN-gamma production in spleens of mice infected with S. typhimurium was analysed at the single cell level using an ELISPOT method. The in vivo IFN-gamma production during the early phase of infection with virulent and avirulent S. typhimurium strains was examined in four mouse strains....

Topics

• Animals
• Colony Count, Microbial
• Disease Susceptibility
• Female
• Genotype
• Interferon-gamma
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Mice, Inbred CBA
• Mice, Inbred DBA