Article
Opposing actions of intact and N-terminal fragments of the human prolactin/growth hormone family members on angiogenesis: an efficient mechanism for the regulation of angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 16 Feb 1999
Struman I, Bentzien F, Lee H, Mainfroid V, D'Angelo G, Goffin V, Weiner R I, Martial J A
Abstract excerpt
Angiogenesis, the process of development of a new microvasculature, is regulated by a balance of positive and negative factors. We show both in vivo and in vitro that the members of the human prolactin/growth hormone family, i.e., human prolactin, human growth hormone, human placental lactogen, and human growth hormone variant are angiogenic whereas their respective 16-kDa N-terminal fragments are antiangiogenic....
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