Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-kappa B loop.

Nature cell biology - 1 Aug 1999

Levkau B, Scatena M, Giachelli C M, Ross R, Raines E W

Abstract excerpt

The transcription factor NF-kappa B is an important regulator of gene expression during immune and inflammatory responses, and can also protect against apoptosis. Here we show that endothelial cells undergo apoptosis when deprived of growth factors. Surviving viable cells exhibit increased activity of NF-kappa B, whereas apoptotic cells show caspase-mediated cleavage of the NF-kappa B p65/ReIA subunit. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspases
Share to Cell Survival
Share to Endothelium, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Feedback

Share to NF-kappa B

Share to Substrate Specificity

Share to Transcription Factor RelA

Source

Identifiers

PMID: 10559921
DOI: 10.1038/12050

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-kappa B loop.PMID 10559921Read ↗

xIAP induces cell-cycle arrest and activates nuclear factor-kappaB : new survival pathways disabled by caspase-mediated cleavage during apoptosis of human endothelial cells.Semantic proximity Read ↗

[Role of the transcription factor NF-kappaB in the cardiac cell].Semantic proximity Read ↗

Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions.Semantic proximity Read ↗

Antagonism of E2F-1 regulated Bnip3 transcription by NF-κB is essential for basal cell survivalSemantic proximity Read ↗

NF-kappaB activation is required for human endothelial survival during exposure to tumor necrosis factor-alpha but not to interleukin-1beta or lipopolysaccharide.Semantic proximity Read ↗

Role of NF-kappaB in p53-mediated programmed cell death.Semantic proximity Read ↗

NF kappa B controls the balance between Fas and tumor necrosis factor cell death pathways during T cell receptor-induced apoptosis via the expression of its target gene A20.Semantic proximity Read ↗

Enhanced caspase activity contributes to aortic wall remodeling and early aneurysm development in a murine model of Marfan syndrome.Semantic proximity Read ↗

Involvement of nuclear factor-kappaB in endothelin-A-receptor-induced proliferation and inhibition of apoptosis.Semantic proximity Read ↗

NF-kappa B activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-kappa B.Semantic proximity Read ↗

Organ-specific roles for transcription factor NF-κB in reovirus-induced apoptosis and diseaseSemantic proximity Read ↗

Adrenomedullin as an Autocrine/Paracrine Apoptosis Survival Factor for Rat Endothelial Cells*Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.