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Article

Bone morphogenetic protein 1 processes prolactin to a 17-kDa antiangiogenic factor

4 Jun 2007

Abstract excerpt

In addition to classical expression patterns in pituitary and placenta and functions in growth and reproduction, members of the small family of hormones that includes prolactin (PRL), growth hormone (GH), and placental lactogen are expressed by endothelia and have angiogenic effects. In contrast, 16- to 17-kDa proteolytic fragments of these hormones have antiangiogenic effects. Here we show that PRL and GH are...

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PMID: 17548836
DOI: 10.1073/pnas.0704179104

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