Article
Differential activation of airway eosinophils induces IL-13-mediated allergic Th2 pulmonary responses in mice.
Allergy - 1 Sept 2015
Jacobsen E A, Doyle A D, Colbert D C, Zellner K R, Protheroe C A, LeSuer W E, Lee N A, Lee J J
Abstract excerpt
BACKGROUND: Eosinophils are hallmark cells of allergic Th2 respiratory inflammation. However, the relative importance of eosinophil activation and the induction of effector functions such as the expression of IL-13 to allergic Th2 pulmonary disease remain to be defined. METHODS: Wild-type or cytokine-deficient (IL-13(-/-) or IL-4(-/-) ) eosinophils treated with cytokines (GM-CSF, IL-4, IL-33) were adoptively...
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