Article
Varying susceptibility to myocardial infarction among C57BL/6 mice of different genetic background.
Journal of molecular and cellular cardiology - 1 Jun 2003
Gorog Diana A, Tanno Masaya, Kabir Alamgir M N, Kanaganayagam Gajen S, Bassi Rekha, Fisher Simon G, Marber Michael S
Abstract excerpt
Genetically manipulated mouse lines are invaluable to investigate the effects of a single gene on sensitivity to ischemia. When choosing appropriate controls, we were concerned that intrinsic, strain-independent but colony-dependent differences may influence the susceptibility to ischemia. We, therefore, compared the infarct:risk volume ratio (I:R%) after 30-min global ischemia in Langendorff-perfused hearts from...
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