Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of copper-zinc superoxide dismutase induces cell growth, hypertrophic phenotype, and apoptosis in neonatal rat cardiac myocytes in vitro.

Circulation research - 23 Jul 1999

Siwik D A, Tzortzis J D, Pimental D R, Chang D L, Pagano P J, Singh K, Sawyer D B, Colucci W S

Abstract excerpt

Oxidative stress has been implicated in the pathophysiology of myocardial failure. We tested the hypothesis that inhibition of endogenous antioxidant enzymes can regulate the phenotype of cardiac myocytes. Neonatal rat ventricular myocytes in vitro were exposed to diethyldithiocarbamic acid (DDC), an inhibitor of cytosolic (Cu, Zn) and extracellular superoxide dismutase (SOD). DDC inhibited SOD activity and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Cardiomegaly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chelating Agents

Share to Hypertrophy

Share to In Situ Nick-End Labeling

Share to Muscle Fibers, Skeletal

Share to Superoxide Dismutase

Share to Superoxides

Source

Identifiers

PMID: 10417396
DOI: 10.1161/01.res.85.2.147

Genes

DDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of copper-zinc superoxide dismutase induces cell growth, hypertrophic phenotype, and apoptosis in neonatal rat cardiac myocytes in vitro.PMID 10417396Read ↗

Novel insights in pathophysiology of antiblastic drugs-induced cardiotoxicity and cardioprotection.Semantic proximity Read ↗

Doxorubicin represses CARP gene transcription through the generation of oxidative stress in neonatal rat cardiac myocytes: possible role of serine/threonine kinase-dependent pathways.Semantic proximity Read ↗

Garlic extract diallyl sulfide protects against dilated cardiomyopathy through inhibition of oxidative stress and apoptosis in miceSemantic proximity Read ↗

H(2)O(2) regulates cardiac myocyte phenotype via concentration-dependent activation of distinct kinase pathways.Semantic proximity Read ↗

Impaired cardiovascular function caused by different stressors elicits a common pathological and transcriptional response in zebrafish embryos.Semantic proximity Read ↗

Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes.Semantic proximity Read ↗

A mechanistic role for cardiac myocyte apoptosis in heart failureSemantic proximity Read ↗

A mechanistic role for cardiac myocyte apoptosis in heart failureSemantic proximity Read ↗

The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathySemantic proximity Read ↗

Calcineurin A β Gene Targeting Predisposes the Myocardium to Acute Ischemia-Induced Apoptosis and DysfunctionSemantic proximity Read ↗

Interleukin-1 beta modulates the growth and phenotype of neonatal rat cardiac myocytes.Semantic proximity Read ↗

Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.