Article
Transmembrane topology of sphingoid long-chain base-1-phosphate phosphatase, Lcb3p.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2003
Kihara Akio, Sano Takamitsu, Iwaki Soichiro, Igarashi Yasuyuki
Abstract excerpt
BACKGROUND: Sphingoid long-chain base-1-phosphates (LCBPs) are thought to act as intracellular signalling molecules in yeast. Lcb3p is a member of the LCBPs-specific phosphatase family (SPP family). Other yeast phosphatases, Lpp1p and Dpp1p, are members of a different lipid phosphatase family (LPP family) known to exhibit broader substrate specificities. Until now, only the membrane topology of mammalian LPP...
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