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Article

Elevation of endogenous sphingolipid long-chain base phosphates kills Saccharomyces cerevisiae cells.

Current genetics - 1 Dec 2001

Zhang X, Skrzypek M S, Lester R L, Dickson R C

Abstract excerpt

Sphingolipid long-chain base phosphates (LCBPs) regulate cell proliferation, movement and differentiation in higher eukaryotes. To study the function of LCBPs in Saccharomyces cerevisiae, we inactivated LCBP breakdown pathways. Elimination of both the Dpll lyase and the Lcb3 phosphatase pathways by gene deletion was lethal, indicating that these enzymes regulate LCBP levels to prevent accumulation. Lethality was...

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PMID: 11795842
DOI: 10.1007/s00294-001-0259-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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