Article
Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects.
Cell death and differentiation - 1 Dec 2008
Cheng W-C, Teng X, Park H K, Tucker C M, Dunham M J, Hardwick J M
Abstract excerpt
Genetic mutations affecting mitochondrial fission and fusion proteins cause human neurological disorders, but are assumed to be well tolerated in yeast. The conserved mitochondrial fission protein Dnm1/Drp1 is required for normal mitochondrial division, but also promotes cell death in mammals and yeast. Fis1, an outer mitochondrial membrane-anchored receptor for Dnm1/Drp1, also can promote cell death in mammals,...
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