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Article

Temporal and spatial dissection of Shh signaling in genital tubercle development.

Development (Cambridge, England) - 1 Dec 2009

Lin Congxing, Yin Yan, Veith G Michael, Fisher Alexander V, Long Fanxin, Ma Liang

Abstract excerpt

Genital tubercle (GT) initiation and outgrowth involve coordinated morphogenesis of surface ectoderm, cloacal mesoderm and hindgut endoderm. GT development appears to mirror that of the limb. Although Shh is essential for the development of both appendages, its role in GT development is much less clear than in the limb. Here, by removing Shh at different stages during GT development in mice, we demonstrate a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19906863
DOI: 10.1242/dev.039768
PMCID: PMC2778743

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