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Article

PPAR{alpha} attenuates the proinflammatory response in activated mesangial cells.

American journal of physiology. Renal physiology - 1 Feb 2009

Kono Keiichi, Kamijo Yuji, Hora Kazuhiko, Takahashi Kyoko, Higuchi Makoto, Kiyosawa Kendo, Shigematsu Hidekazu, Gonzalez Frank J, Aoyama Toshifumi

Abstract excerpt

The activated mesangial cell is an important therapeutic target for the control of glomerulonephritis. The peroxisome proliferator-activated receptor alpha (PPARalpha) has attracted considerable attention for its anti-inflammatory effects; however, its roles in the mesangial cells remain unknown. To determine the anti-inflammatory function of PPARalpha in mesangial cells, wild-type and Ppara-null cultured...

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Source

Identifiers

PMID: 19036849
DOI: 10.1152/ajprenal.00484.2007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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