Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

c-Jun NH2-terminal kinase-dependent Fas activation contributes to etoposide-induced apoptosis in p53-mutated prostate cancer cells.

The Prostate - 1 Jun 2003

Shimada Keiji, Nakamura Mitsutoshi, Ishida Eiwa, Kishi Munehiro, Yonehara Shin, Konishi Noboru

Abstract excerpt

BACKGROUND: The death receptor, Fas, has recently been demonstrated to contribute the chemotherapeutic agents-induced apoptosis, however, the detail mechanisms have yet to be fully understood, especially in prostate cancer cells. METHODS: PC-3 and DU145 stably transfected with dominant negative form of Fas-associated death domain (FADD) or specific kinase of c-Jun NH2-terminal kinase (JNK) (mitogen-activated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Phytogenic
Share to Caspases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Fragmentation

Share to Etoposide

Share to fas Receptor

Share to Fatty Acid Desaturases

Share to JNK Mitogen-Activated Protein Kinases

Share to Mitogen-Activated Protein Kinase Kinases

Source

Identifiers

PMID: 12712406
DOI: 10.1002/pros.10227

Genes

FADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

c-Jun NH2-terminal kinase-dependent Fas activation contributes to etoposide-induced apoptosis in p53-mutated prostate cancer cells.PMID 12712406Read ↗

Apoptosis in prostate cancer: progressive and therapeutic implications (Review).Semantic proximity Read ↗

Cisplatin-induced apoptosis in human malignant testicular germ cell lines depends on MEK/ERK activationSemantic proximity Read ↗

Heterogeneous apoptotic responses of prostate cancer cell lines identify an association between sensitivity to staurosporine-induced apoptosis, expression of Bcl-2 family members, and caspase activationSemantic proximity Read ↗

Inhibitory member of the apoptosis-stimulating protein of p53 (ASPP) family promotes growth and tumorigenesis in human p53-deficient prostate cancer cellsSemantic proximity Read ↗

Molecular mechanisms for apigenin‐induced cell‐cycle arrest and apoptosis of hormone refractory human prostate carcinoma DU145 cellsSemantic proximity Read ↗

Low-dose 12-O-tetradecanoylphorbol-13-acetate enhances tumor necrosis factor related apoptosis-inducing ligand induced apoptosis in prostate cancer cells.Semantic proximity Read ↗

Influences of TP53 and the anti-aging DDR1 receptor in controlling Raf/MEK/ERK and PI3K/Akt expression and chemotherapeutic drug sensitivity in prostate cancer cell lines.Semantic proximity Read ↗

Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activationSemantic proximity Read ↗

10-formyltetrahydrofolate dehydrogenase-induced c-Jun-NH2-kinase pathways diverge at the c-Jun-NH2-kinase substrate level in cells with different p53 status.Semantic proximity Read ↗

p53 expression controls prostate cancer sensitivity to chemotherapy and the MDM2 inhibitor Nutlin-3Semantic proximity Read ↗

Effect of p53 gene polymorphism on functions of prostate cancer cells.Semantic proximity Read ↗

RKIP Sensitizes Prostate and Breast Cancer Cells to Drug-induced ApoptosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.