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Article

Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo.

The pharmacogenomics journal - 1 Aug 2011

de Bock C E, Garg M B, Scott N, Sakoff J A, Scorgie F E, Ackland S P, Lincz L F

Abstract excerpt

Two known polymorphisms in the 5' enhancer region (ER) of the thymidylate synthase (TS) gene, a variable number of tandem repeats of a 28 bp sequence (2R/3R) and a further G>C single nucleotide substitution within the repeats, result in genotypes with 0-5 functional upstream stimulatory factor (USF) E-box consensus elements. However, the relationship between these polymorphisms, regulation of TS expression and...

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Source

Identifiers

PMID: 20531375
DOI: 10.1038/tpj.2010.43

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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