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Article

Structures of Burkholderia thailandensis nucleoside kinase: implications for the catalytic mechanism and nucleoside selectivity.

Acta crystallographica. Section D, Biological crystallography - 1 Nov 2011

Yasutake Yoshiaki, Ota Hiroko, Hino Emisa, Sakasegawa Shin-ichi, Tamura Tomohiro

Abstract excerpt

The nucleoside kinase (NK) from the mesophilic Gram-negative bacterium Burkholderia thailandensis (BthNK) is a member of the phosphofructokinase B (Pfk-B) family and catalyzes the Mg(2+)- and ATP-dependent phosphorylation of a broad range of nucleosides such as inosine (INO), adenosine (ADO) and mizoribine (MZR). BthNK is currently used in clinical practice to measure serum MZR levels. Here, crystal structures of...

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Identifiers

PMID: 22101821
DOI: 10.1107/S0907444911038777

Genes

ADO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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