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Article

A novel allosteric site employs a conserved inhibition mechanism in human kidney-type glutaminase.

The FEBS journal - 1 May 2023

Shankar Srihari, Ramachandran Sarath, Tulsian Nikhil, Radhakrishnan Sridhar, Jobichen Chacko, Sivaraman J

Abstract excerpt

Glutaminase catalyses the metabolic process called glutaminolysis. Cancer cells harness glutaminolysis to increase energy reserves under stressful conditions for rapid proliferation. Glutaminases are upregulated in many tumours. In humans, the kidney-type glutaminase (KGA) isoform is highly expressed in the kidney, brain, intestine, foetal liver, lymphocytes and in many tumours. Glutaminase inhibition is shown to...

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PMID: 36259273
DOI: 10.1111/febs.16658

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