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Article

Life without dihydrofolate reductase FolA.

Trends in microbiology - 1 May 2003

Myllykallio Hannu, Leduc Damien, Filee Jonathan, Liebl Ursula

Abstract excerpt

Reduced folate derivatives participate in numerous reactions of bacterial intermediary metabolism. Consequently, the well-characterized enzyme implicated in the formation of tetrahydrofolate--dihydrofolate reductase FolA--was considered to be essential for bacterial growth. However, comparative genomics has revealed several bacterial genome sequences that appear to lack the folA gene. Here, we provide in silico...

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Identifiers

PMID: 12781525
DOI: 10.1016/s0966-842x(03)00101-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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