Folate metabolite profiling of different cell types and embryos suggests variation in folate one-carbon metabolism, including developmental changes in human embryonic brain

Abstract excerpt

Folates act as co-factors for transfer of one-carbon units for nucleotide production, methylation and other biosynthetic reactions. Comprehensive profiling of multiple folates can be achieved using liquid chromatography tandem mass spectrometry, enabling determination of their relative abundance that may provide an indication of metabolic differences between cell types. For example, cell lines exposed to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Birth, Development, and Health
• Share to Epigenetics and DNA Methylation
• Share to Folate and B Vitamins Research