Article
Increased susceptibility to nonalcoholic fatty liver disease in heterozygotes for the mutation responsible for hereditary hemochromatosis.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Mar 2003
Valenti L, Dongiovanni P, Fracanzani A L, Santorelli G, Fatta E, Bertelli C, Taioli E, Fiorelli G, Fargion S
Abstract excerpt
BACKGROUND: Insulin resistance is a key feature of nonalcoholic fatty liver disease. Patients with hereditary hemochromatosis, a disease characterized by progressive iron overload due, in most cases, to homozygosity for C282Y mutation in the HFE gene, have often decreased insulin sensitivity and release. AIMS: To determine whether increased iron parameters/heterozygosity for the mutations of the HFE gene confer...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.