Article
Metabolic alterations, HFE gene mutations and atherogenic lipoprotein modifications in patients with primary iron overload.
Clinical science (London, England : 1979) - 1 May 2015
Meroño Tomás, Brites Fernando, Dauteuille Carolane, Lhomme Marie, Menafra Martín, Arteaga Alejandra, Castro Marcelo, Saez María Soledad, Ballerga Esteban González, Sorroche Patricia, Rey Jorge, Lesnik Philippe, Sordá Juan Andrés, Chapman M John, Kontush Anatol, Daruich Jorge
Abstract excerpt
Iron overload (IO) has been associated with glucose metabolism alterations and increased risk of cardiovascular disease (CVD). Primary IO is associated with mutations in the HFE gene. To which extent HFE gene mutations and metabolic alterations contribute to the presence of atherogenic lipoprotein modifications in primary IO remains undetermined. The present study aimed to assess small, dense low-density...
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