Article
A codon-based model of host-specific selection in parasites, with an application to the influenza A virus.
Molecular biology and evolution - 1 Aug 2003
Forsberg Roald, Christiansen Freddy Bugge
Abstract excerpt
Parasites sometimes expand their host range by acquiring a new host species. After a host change event, the selective regime acting on a given parasite gene may change as a result of host-specific adaptive alterations of protein functionality or host-specific immune-mediated selection. We present a codon-based model that attempts to include these effects by allowing the position-specific substitution process to...
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