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Identifying Changes in Selective Constraints: Host Shifts in Influenza

12 Nov 2009

Abstract excerpt

The natural reservoir of Influenza A is waterfowl. Normally, waterfowl viruses are not adapted to infect and spread in the human population. Sometimes, through reassortment or through whole host shift events, genetic material from waterfowl viruses is introduced into the human population causing worldwide pandemics. Identifying which mutations allow viruses from avian origin to spread successfully in the human...

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PMID: 19911053
DOI: 10.1371/journal.pcbi.1000564

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