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Article

The individualization of cancer therapy: the unexpected role of p53.

Transactions of the American Clinical and Climatological Association - 1 Jan 2006

Hait William N, Yang Jin-Ming

Abstract excerpt

Our laboratory discovered that p53 can regulate the sensitivity to cancer therapies by affecting three critical aspects of cancer pharmacology: 1). The expression of drug targets; 2). the access of drugs to intracellular targets; and the response to DNA damage. We review the effects of p53 on antimicrotubule drugs through transcriptional regulation of MAP4 and stathmin (Oncoprotein 18). These two p53-regulated...

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Share to Antineoplastic Agents
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Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Genes, p53

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Share to Multidrug Resistance-Associated Proteins

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Source

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Identifiers

PMID: 18528466
PMCID: PMC1500917

Genes

MAP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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