Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NMR study of the Z-DNA binding mode and B-Z transition activity of the Zα domain of human ADAR1 when perturbed by mutation on the α3 helix and β-hairpin.

Archives of biochemistry and biophysics - 15 Sept 2014

Jeong Minjee, Lee Ae-Ree, Kim Hee-Eun, Choi Yong-Geun, Choi Byong-Seok, Lee Joon-Hwa

Abstract excerpt

The Zα domains of human ADAR1 (ZαADAR1) bind to Z-DNA via interaction mediated by the α3-core and β-hairpin. Five residues in the α3 helix and four residues in the β-hairpin play important roles in Zα function, forming direct or water-mediated hydrogen bonds with DNA backbone phosphates or interacting hydrophobically with DNA bases. To understand the roles of these residues during B-Z transition of duplex DNA, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Deaminase
Share to Amides

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Amino Acid Sequence

Share to Magnetic Resonance Spectroscopy

Share to Models, Molecular

Share to Nucleic Acid Conformation

Share to Protein Structure, Secondary

Share to Protein Structure, Tertiary

Source

Identifiers

PMID: 25010446
DOI: 10.1016/j.abb.2014.06.026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NMR study of the Z-DNA binding mode and B-Z transition activity of the Zα domain of human ADAR1 when perturbed by mutation on the α3 helix and β-hairpin.PMID 25010446Read ↗

Novel interaction of the Z-DNA binding domain of human ADAR1 with the oncogenic c-Myc promoter G-quadruplex.Semantic proximity Read ↗

Biological consequences of Z-nucleic acid sensing by ZBP1 and ADAR1.Semantic proximity Read ↗

The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA.Semantic proximity Read ↗

The Role of the Z-DNA Binding Domain in Innate Immunity and Stress GranulesSemantic proximity Read ↗

The Zα domain of fish PKZ converts DNA hairpin with d(GC)(n) inserts to Z-conformation.Semantic proximity Read ↗

Human genomic Z-DNA segments probed by the Z alpha domain of ADAR1.Semantic proximity Read ↗

The YTHDC1 glutamate-rich domain docks to the ADAR1 Zα Domain, linking the N <sup>6</sup> -methyladenosine modification of pre-mRNAs to dsRNA editingSemantic proximity Read ↗

Signatures of Specific DNA Binding by the AT-Rich Interaction Domain of BAF250a.Semantic proximity Read ↗

A sodium/potassium switch for G4-prone G/C-rich sequences.Semantic proximity Read ↗

A role of basic residues and the putative intercalating phenylalanine of the HMG-1 box B in DNA supercoiling and binding to four-way DNA junctions.Semantic proximity Read ↗

Structure of a histidine-X4-histidine zinc finger domain: insights into ADR1-UAS1 protein-DNA recognition.Semantic proximity Read ↗

Solution structure of the Z0 domain from transcription repressor BCL11A sheds light on the sequence properties of protein‐binding zinc fingersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.