Hox proteins functionally cooperate with the GC box-binding protein system through distinct domains.

Abstract excerpt

Hox genes encode a transcriptional factor that plays a key role in regulating position-specific cartilage pattern formation. We found that Hoxa-13 and Hoxd-13, which are members of the Abd-B subfamily of Hox genes and are crucial for the autopod development of the limb, stimulate transcription from the Bmp-4 promoter. This stimulation was dependent on the GC box within the promoter and independent of the putative...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chickens
• Share to Cytoplasm
• Share to Genes, Dominant