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Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of β-catenin degradation.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 May 2014

Kim Joo-Hyun, Kim Young Ho, Song Gyu-Yong, Kim Dong-Eun, Jeong Yong-Joo, Liu Kwang-Hyeon, Chung Young-Hwa, Oh Sangtaek

Abstract excerpt

Ursolic acid (UA) and corosolic acid (CA), naturally occurring pentacyclic triterpene acids, exhibit antiproliferative activities against various cancer cells, but a clear chemopreventive mechanism of these triterpenoids in colon cancer cells remains to be answered. Here we used a cell-based reporter system for detection of β-catenin response transcription (CRT) to identify UA as an antagonist of the...

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PMID: 24566423
DOI: 10.1016/j.fct.2014.02.019

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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