Article
Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR)
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Aug 1998
Goyette P, Pai A, Milos R, Frosst P, Tran P, Chen Z, Chan M, Rozen R
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. A human cDNA for MTHFR, 2.2 kb in length, has been expressed and shown to result in a catalytically acti...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- DNA, Complementary
- Exons
- Genomic Library
- Humans
- Introns
- Methylenetetrahydrofolate Reductase (NADPH2)
- Mice
- Molecular Sequence Data
- Mutation
- Oxidoreductases Acting on CH-NH Group Donors
- Recombinant Proteins
- Sequence Alignment
- Sequence Analysis, DNA
- Sequence Homology, Amino Acid