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Article

Leukocyte-Endothelium Interaction Promotes SDF-1-dependent Polarization of CXCR4

1 Aug 2003

Abstract excerpt

Chemokine-driven migration is accompanied by polarization of the cell body and of the intracellular signaling machinery. The extent to which chemokine receptors polarize during chemotaxis is currently unclear. To analyze the distribution of the chemokine receptor CXCR4 during SDF-1 (CXCL12)-induced chemotaxis, we retrovirally expressed a CXCR4-GFP fusion protein in the CXCR4-deficient human hematopoietic...

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PMID: 12766157
DOI: 10.1074/jbc.m304764200

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