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Article

Intracellular trafficking and endocytosis of CXCR4 in fetal mesenchymal stem/stromal cells

16 May 2014

Abstract excerpt

BACKGROUND: Fetal mesenchymal stem/stromal cells (MSC) represent a developmentally-advantageous cell type with translational potential.To enhance adult MSC migration, studies have focussed on the role of the chemokine receptor CXCR4 and its ligand SDF-1 (CXCL12), but more recent work implicates an intricate system of CXCR4 receptor dimerization, intracellular localization, multiple ligands, splice variants and...

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PMID: 24885150
DOI: 10.1186/1471-2121-15-15

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