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Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes.

Human molecular genetics - 12 Oct 2000

Mammarella S, Romano F, Di Valerio A, Creati B, Esposito D L, Palmirotta R, Capani F, Vitullo P, Volpe G, Battista P, Della Loggia F, Mariani-Costantini R, Cama A

Abstract excerpt

The insulin receptor substrate-2 (IRS-2) is a major insulin signalling molecule. IRS-2 inactivation in mice induces a form of diabetes characterized by peripheral insulin resistance and reduced beta cell mass. We tested the hypothesis that a common non-conservative amino acid substitution of IRS-2 (G1057D) might interact with overweight in the pathogenesis of type 2 diabetes. The variant was genotyped in 193...

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PMID: 11030756
DOI: 10.1093/hmg/9.17.2517

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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