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Article

Global structural changes in annexin 12. The roles of phospholipid, Ca2+, and pH.

The Journal of biological chemistry - 8 Aug 2003

Isas J Mario, Patel Darshana R, Jao Christine, Jayasinghe Sajith, Cartailler Jean-Philippe, Haigler Harry T, Langen Ralf

Abstract excerpt

Ca2+-dependent membrane interaction has long been recognized as a general property of the annexin (ANX) family of proteins. More recently, it has become clear that ANXs can also undergo Ca2+-independent membrane interactions at mildly acidic pH. Here we use site-directed spin labeling in combination with circular dichroism and biochemical labeling methods to compare the structure and membrane topography of these...

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PMID: 12756261
DOI: 10.1074/jbc.M301228200

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