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Article

A helical hairpin region of soluble annexin B12 refolds and forms a continuous transmembrane helix at mildly acidic pH.

The Journal of biological chemistry - 16 Sept 2005

Kim Yujin E, Isas Jose Mario, Haigler Harry T, Langen Ralf

Abstract excerpt

Annexins are soluble proteins that are best known for their ability to undergo reversible Ca(2+)-dependent binding to the surface of phospholipid bilayers. Recent studies, however, have shown that annexins also reversibly bind to membranes in a Ca(2+)-independent manner at mildly acidic pH. We investigated the structural changes that occur upon pH-dependent membrane binding by performing a nitroxide scan on the...

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Identifiers

PMID: 15975928
DOI: 10.1074/jbc.M505017200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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