Annexin V: the key to understanding ion selectivity and voltage regulation?

doi:10.1016/0968-0004(94)90002-7

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Article

Annexin V: the key to understanding ion selectivity and voltage regulation?

Trends in biochemical sciences - 1 Jul 1994

Demange P, Voges D, Benz J, Liemann S, Göttig P, Berendes R, Burger A, Huber R

Abstract excerpt

Annexin V is a Ca(2+)-dependent membrane-binding protein that forms voltage-dependent Ca2+ channels in phospholipid bilayers and is the first ion channel to be structurally and functionally characterized. Data outlined here indicate that key amino acid residues act as selectivity filters and volt...

Topics

Annexin A5
Calcium Channels
Cell Membrane
DNA Mutational Analysis
Humans
Ion Channel Gating
Ion Channels
Mutation
Protein Conformation
Structure-Activity Relationship

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