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Article

Calcium Signaling Consequences of RyR2-S4938F Mutation Expressed in Human iPSC-Derived Cardiomyocytes.

International journal of molecular sciences - 18 Oct 2023

Toth Noemi, Zhang Xiao-Hua, Zamaro Alexandra, Morad Martin

Abstract excerpt

Type-2 ryanodine receptor (RyR2) is the major Ca2+ release channel of the cardiac sarcoplasmic reticulum (SR) that controls the rhythm and strength of the heartbeat, but its malfunction may generate severe arrhythmia leading to sudden cardiac death or heart failure. S4938F-RyR2 mutation in the carboxyl-terminal was expressed in human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CMs) using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37894987
DOI: 10.3390/ijms242015307
PMCID: PMC10607246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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